Faculty

Jing-Yuan Chuang, PhD (莊淨媛 博士)

Jing-Yuan Chuang, PhD (莊淨媛 博士)

Associate Professor Department of Medical Laboratory Science and Biotechnology, China Medical University
Email: jychuang@mail.cmu.edu.tw
Phone: 886-4-22053366 ext. 7213
Fax: 886-4-22057414
Office: 14 F, Li-Fu Teaching Building
Mailing Address: Department of Medical Laboratory Science and Biotechnology, China Medical University
91, Hsueh-Shih Rd., Taichung, Taiwan 40402, R.O.C.
40402 台中市北區學士路91號 中國醫藥大學醫學檢驗生物技術學系

 

Education

Institution Nation Department/Program Degree Dates
National Taiwan University, College of Medicice Taiwan, ROC Department of Pathology PhD From 1991 / 8 to 1996 / 7
National Taiwan University, College of Medicice Taiwan, ROC Institute of Biochemistry and Molecular Biology Master From 1989 / 8 to 1991 / 7
China Medical University Taiwan, ROC Medical Technology Bachelor From 1983 / 9 to 1987 / 6

 

Current Position

Institution Department/Program Position Duration
China Medical University Department of Medical Laboratory Science and Biotechnology Associate Professor From 1997 / 8 to Now

 

Professional Experience

Institution Department/Program Position Duration
China Medical University Department of Medical Laboratory Science and Biotechnology Director From 1997 / 8 to 2000 / 7
China Medical University School of Medicine Associate Professor From 1997 / 3 to 1997 / 7
Acdemia Sinica Institute of Biomedical Sciences Postdoctor From 1996 / 8 to 1997 / 7
University of California, Irvine School of Medicine, Dept. of Biological Chemistry Visiting Scholar From  2013  /to 2103 / 7

Speciality

  • Molecular Oncology
  • Cell Biology
  • Haematology

Research Field

  • Cancer and Chemokine Network

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Publication

I. Paper

  1. Jing-Yuan Chuang, Po-Chun Chen, Ching-Wen Tsao, An-Chen Chang, Ming-Yu Lein, Ching-Chia Lin, Shih-Wei Wang, Chiao-Wen Lin, Chih-Hsin Tang. (2015). WISP-1, a novel angiogenic regulator of the CCN family, promotes oral squamous cell carcinoma angiogenesis through VEGF-A expression.  Oncotarget, 6(6), Jan 30. [Epub ahead of print] (Impact factor 6.63, Ranking 17/203, oncology )
  2. Chuang JY, Chang PC, Shen YC, Lin C, Tsai CF, Chen JH, Yeh WL, Wu LH, Lin HY, Liu YS, Lu DY. (2014). Regulatory effects of fisetin on microglial activation. Molecules, Jun 26; 19(7):8820-39. doi: 10.3390/molecules19078820. (Impact factor 2.10, Ranking 30/58, CHEMISTRY, ORGANIC )
  3. Chuang, J. Y., Huang, Y. L., Yen, W. L., Chiang, I. P., Tsai, M. H., & Tang, C. H. (2014). Syk/JNK/AP-1 signaling pathway mediates interleukin-6-promoted cell migration in oral squamous cell carcinoma. Int J Mol Sci, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15(1), 545-559. (Impact factor 2.34, Ranking 52/148, CHEMISTRY, MULTIDISCIPLINARY )
  4. Chuang, J. Y., Chang, A. C., Chiang, I. P., Tsai, M. H., & Tang, C. H. (2013). Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells. PLoS One, 8(10), e78022. (Impact factor 3.53 , Ranking 8/55, MULTIDISCIPLINARY SCIENCES )
  5. Chuang, J. Y., Tsai, C. F., Chang, S. W., Chiang, I. P., Huang, S. M., Lin, H. Y., Lu, D. Y. (2013). Glial cell line-derived neurotrophic factor induces cell migration in human oral squamous cell carcinoma. Oral Oncol, 49(12), 1103-1112. (Impact factor 3.03, Ranking 5/83, DENTISTRY, ORAL SURGERY & MEDICINE )
  6. Jing-Yuan Chuang, Nuo-Yi Yu, I-Ping Chiang, Chih-Ho Lai, Chia-Der Lin, Chih-Hsin Tang* Cyr61 increases matrix metalloproteinase-3 expression and cell motility in human oral squamous cell carcinoma cells. Journal of Cellular Biochemistry  (2012) June 113(6):1977-86. (Impact factor 3.37, Ranking 107/291, BIOCHEMISTRY & MOLECULAR BIOLOGY)
  7. Jing-Yuan Chuang, Wan-YuYang, Chih-Ho Lai, Chia-Der Lin, Ming-Hsui Tsai, Chih-Hsin Tang* CTGF inhibits cell motility and COX-2 expression in oral cancer cells. INTERNATIONAL IMMUNOPHARMACOLOGY (2011) Aug 11(8):948-54,. (Impact factor 2.71, Ranking 95/256, PHARMACOLOGY & PHARMACY)
  8. Tzu-Li Lu, Jing-Yuan Chuang, Jai-Sing Yang, Shau-Ting Chiu, Nai-Wan Hsiao, Mei-Chen Wu, Shih-Hsiung Wu, and Ching-Hsiang Hsu*. Production of Active Nonglycosylated Recombinant B-chain of Type-2 Ribosome-inactivating Protein from Viscum articulatum and its Biological Effects on Peripheral Blood Mononuclear cells. Evidence-Based Complementary and Alternative Medicine (2011) Vol 2011 (Impact factor 2.18, Ranking 6/22, INTEGRATIVE & COMPLEMENTARY MEDICINE)
  9. Hsiao-Yun Lin, Chih-Hsin Tang, Jia-Hong Chen, Jing-Yuan Chuang, Ssu-Ming Huang, Tzu-Wei Tan, Chih-Ho Lai, Dah-Yuu Lu*. Peptidoglycan induces interlukin-6 expression through the TLR2 Receptor, JNK, c-Jun and AP-1 pathways in microglia. Journal of Cellular Physiology (2010), 226(6): 1573–1582. (Impact factor 4.22, Ranking 13/80, PHYSIOLOGY)
  10. JING-YUAN CHUANG, WEI-HUNG YANG, HSIEN-TE CHEN, CHUN-YIN HUANG, TZU-WEI TAN, YUH-TZY LIN, CHIN-JUNG HSU, YI-CHIN FONG, AND CHIH-HSIN TANG* CCL5/CCR5 axis promotes the motility of human oral cancer cells. Journal of Cellular Physiology(2009) 220(2):418-26. (Impact factor 4.22, Ranking 13/80, PHYSIOLOGY)
  11. J.Y. Chuang, S.S. Yang, Y.T. Lu, Y.Y. Hsieh, C.Y. Chen, S.C. Chang, C.S. Chang, H.Z. Yeh, J.H. Kao∗. IL-10 promoter gene polymorphisms and sustained response to combination therapy in Taiwanese chronic hepatitis C patients. Digestive and Liver Disease (2009) 41(6):424–430. (Impact factor 2.89, Ranking 28/75, GASTROENTEROLOGY & HEPATOLOGY)
  12. CH Tang*, JY Chuang, Yi-Chin Fong, Ming-Chei Maa, Tzong-Der Way and Chien-Hui Hung, Bone-derived SDF-1 stimulates IL-6 Release via CXCR4, ERK and NF-κB pathways and promoting osteoclastogenesis in human oral cancer cells. Carcinogenesis (2008) Aug; 29(8):1483-92. (Impact factor 5.27, Ranking 32/203, ONCOLOGY)
  13. Jing-Yuan Chuang, Yung-Feng Huang, Hsu-Feng Lu, Jai-Sing Yang, Te-Mao Li, and Jing-Gung Chung*. Coumarin Incuces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells through a Mitochondria- and Caspase 3- dependent Mechanism and NF-κB Down-regulation. IN VIVO (2007) 21:1003-1010 (SCI)
  14. S.C. Chen*, S.C. Lin, S.H. Liang and J.Y. Chuang.  Detection of Gentoxicity of Benzidine and its Deriatives with the Escherichia Coli DJ 702 LacZ Reversion mutagenicity Assay. Letters in Applied Microbiology (2006) 43 : 22-26. (SCI)
  15. Jing-Yuan Chuang, Yueh-Yu Tsai, Ssu-Ching Chen, Tian-Jye Hsieh and Jing-Gung Chung* Induction of G0/G1 Arrest and Apoptosis by 3-Hydroxycinnamic Acid in Human Cervix Epithelial Carcinoma (HeLa) Cells. IN VIVO (2005) 19: 683-688. (SCI)
  16. Yu-Ching Li, Yu-Sheng Tyan, Yih-Min Lee, Tang-Yi Tsao, Jing-Yuan Chuang, Hsiu-Maan Kuo, Te-Chun Hsia, Jen-Hung Yang and Jing-Gung Chung*  (2005) N-Acetyltransferase is Involved in Baicalein-induced N-Acetylation of 2-Aminofluorene and DNA-2-Aminofluorence Adduct Formation in Human Leukemia HL-60 Cells. IN VIVO 19:399-406. (SCI)
  17. Hsu-Feng Lu, Mei-Fen Tsou, Jaung-Gung Lin, Chin-Chin Ho, Jia-You Liu, Jing-Yuan Chuang and Jing-Gung Chung* (2005) Ellagic Acid Inhibits Growth and Arylamine N-Acetyltransferase Activity and Gene Expression in Staphylococcus aureus. IN VIVO 19:195-200. (SCI)
  18. S.S. Lin, J.G. Chung*, J.P. Lin, J.Y. Chuang, W.C. Chang, J.Y. Wu, Y.S. Tyan (2005) Berberine Inhibits Arylamine N-acetyltransferase Activity and Gene Expression in Mouse Leukemia L1210 Cells. Phytomedicine 12: 351-358. (SCI)
  19. Lii-Tzu Wu, Mei-Fen Tsou, Chin-Chin Ho, Jing-Yuan Chuang, Hsiu-Maan Kuo, Jing-Gung Chu. (2005) Berberine Inhibits Arylamine N-Acetyltransferase Activity and Gene Expression in Salmonella Typhi. Current Microbiology. Vol. 51, pp. 255–261.
  20. Shiu-Feng Tung#, Jing-Yuan Chuang#, Chin-Tarng lin, Ming-Yang Lai, Cheng-WenWu, and Young-Sun Lin.(1999)  Inhibition of hTAFII32-binding implicated in the Transcriptional Repression by Central Regions of Mutant p53 Proteins. J. Biol. Chem. 274:7748-7755. (Impact factor 4.60, Ranking 65/291, BIOCHEMISTRY & MOLECULAR BIOLOGY),# Two authors contributed equally
  21. Jing-Yuan Chuang, Chin-Tarng Lin, Cheng-Wen Wu, and Young-Sun Lin.(1995) A Movable and Regulable Inactivation Function within the Central Region of a Temperature-sensitive p53 Mutant. J. Biol. Chem. 270: 23899-23902. (Impact factor 4.60, Ranking 65/291, BIOCHEMISTRY & MOLECULAR BIOLOGY)
  22. Yu-Shen Hsu, Fen-Mei Tang, Wei-Li Liu, Jing-Yuan Chuang, Ming-Yang Lai, and Young-Sun Lin. (1995)  Transcriptional Regulation by p53. Functional interactions among multiple regulatory domain. J. Biol. Chem. 270: 6966-6974. (Impact factor 4.60, Ranking 65/291, BIOCHEMISTRY & MOLECULAR BIOLOGY)

II. Conference paper

  • Ching-Wen Tsao, Jing-Yuan Chuang, Chih-Hsin Tang. WISP-1 Increases Angiogenesis and VEGF-A Expression  in Human Oral Squamous Cell Carcinomas. AACR Annual Meeting 2014/4/5-9.
  • Ching-Wen Tsao, Jing-Yuan Chuang, Chih-Hsin Tang. WISP-1 Increases Angiogenesis and VEGF-A Expression  in Human Oral Squamous Cell Carcinomas. The 29th Joint Annual Conference of Biomedical Science.2014/3/15-16.
  • Chi-Jou Su, Hsiao-Hui Kuo, Jing-Yuan Chuang, and Ling-Huei Yih. Heat Shock Factor-1 Was Required for Ras-induced Transformatin in Human Bronchial Epithelial Cells. The 29th Joint Annual Conference of Biomedical Science.2014/3/15-16. 
  • An-Chen Chang, Jing-Yuan Chuang, Chih-Hsin Tang. WISP-1 Increases Cell Migration and ICAM-1 Expression in Human Oral Squamous Cells. AACR Annual Meeting, 2013/4/6-10.
  • 嚴為伶, Chuang Jing-Yuan, Tang Chih-Hsin. IL-6 enhances migration and ICAM-1 expression of human oral squamous cell carcinoma involves IL-6 receptor signaling pathway. AACR Annual Meeting, 2012/3/31-2012/4/4.
  • Yi-Chung Shen, Hsiao-Yun Lin, Chuang Jing-Yuan, Lu Dah-Yuu. Fisetin Inhibits Reactive Oxygen Species Production and Up-regulates Anti-inflammatory Cytokine Expressions in Microglia. The 28th Joint Annual Conference of Biomedical Science. 2013/3/23-24.
  • An-Chen Chang, Jing-Yuan Chuang, Chih-Hsin Tang. WISP-1 Increases Cell Migration and ICAM-1 Expression in Human Oral Cancer Cells. The 27th Joint Annual Conference of Biomedical Science.2012/3/17-18.
  • Shu-Wen Chang, Jing-Yuan Chuang,Dah-Yuu Lu. Glial cell line-derived  neurotrophic factor stimulates cell movement and regulates matrix metalloproteinase-13 activation in cancer cell. Society for Neuroscience, 2011/11/12-16
  • Nuo-Yi Yu, Jing-Yuan Chuang, Chih-Hsin Tang. Cyr61 Increases Cell Migration and MMP-3 Expression via v3 and 6 Integrin, FAK, ERK, and NF-κB–Dependent Pathway in Human Oral Squamous Carcinoma Cells. AACR 102nd Annual Meeting. 2011/4/2-6.
  • Wan-Yu Yang, Jing-Yuan Chuang, Chih-Hsin Tang. CTGF inhibits cell motility in oral cancer cells through reducing COX-2 expression. AACR 102nd Annual Meeting. 2011/4/2-6.
  • Shu-Wen Chang, Jing-Yuan Chuang, Dah-Yuu Lu. Glial cell line-derived  neurotrophic factor stimulates cell movement and regulates matrix metalloproteinase-13 activation in cancer cell. The 26th Joint Annual Conference of Biomedical Science,2011/3/19-20
  • Shu-Wen Chang, Jing-Yuan Chuang, Dah-Yuu Lu. Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in human oral squamous cell carcinoma. Gordon Research Conference,2011/03/06-11
  • Nuo-Yi Yu, Jing-Yuan Chuang, Chih-Hsin Tang. Cyr61 Increases Cell Migration in Human Oral Cancer Cells through FAK, ERK, and NF-κB Pathway. 第二十五屆生醫年會,2010/3/27-28
  • Wan-Yu Yang, Jing-Yuan Chuang, Chih-Hsin Tang. Connective Tissue Growth Factor Decreases Migration of Oral Cancer Cells through FAK, AKT, and AP-1 Signaling Pathway. 第二十五屆生醫年會,2010/3/27-28
  • Yi-Lin Huang, Chih-Hsu Lin, Hsieh-Cheng Chen, I-Ping Chiang, Jing-Yuan Chuang*. Chemokine CXCL12 Mediates Cellular Proliferation in Oral Squamous Cell Carcinoma through both CXCR4 and CXCR7 Receptors. 第二十五屆生醫年會,2010/3/27-28
  • Ching-Yuan Chuang* Chemokine CXCL12 Involved in Cellular Proliferatin in Oral Squamous Cell Carcinoma,2008醫學檢驗生物技術新知研討會(受邀演講),2008/5/24-25
  • Hsieh-Cheng Chen, I-Ping Chiang, Chia-Yu Chen, Tsung-Jen Huang, Ching-Yuan Chuang*,Chemokine CXCL12 Is Overexpressed and Involved in Cellular Proliferation in Oral Squamous Cell Carcinoma. 第二十三屆生醫年會,2008/3/29-30.
  • 陳協成、陳佳玉、黃琮仁、莊淨媛*,趨化激素受體CXCR4與口腔癌之關係,2007,中國醫藥大學2007研究學習群校級研究成果發表會2007/12/1-2
  • 莊淨媛、楊仁宏、鄒梅芬、吳志忠、李德茂、鄭國柱、鍾景光*Curcumin Induced G2/M Arrest and Down-regulation of NFkB Activation and Up-regulation of Caspase-3 Activity Led to Apoptosis in Human Bladder Cancer T24 Cells,第二十屆天然藥物研討會,國立中國醫藥研究所,2005/6/24-25.
  • 黃永豐、莊淨媛、鍾景光* Coumarin Inhibits Proliferation of Human Cervical Cancer Cells (HeLa) via Inducing Cell Cycle Arrest and Apoptosis,Experimental Biology/International Congress of Physiological Sciences, San Diego Convention Center,2005/4/2-6
  • 黃永豐、鍾景光、楊婷婷、莊淨媛*  Coumarin Induces Cytostatic and Apoptosis Effects on Human Cervical Carcinoma Cells via Generation of Reactive Oxygen Species. 第二十屆生醫年會,國防大學國防醫學院,2005/3/26-27.
  • 蔡悅瑜、莊淨媛* Induction of Apoptosis by 3-Hydroxycinnamic Acid in Human Cervical Carcinoma Cells through p53 pathway.第二十屆生醫年會,國防大學國防醫學院,2005/3/26-27.
  • Jing-Yuan Chuang, Chin-Tarng Lin, and Young-Sun Lin.(1996)  A Movable and Regulable Inactivation Function within the Central Region of A Temperature-Sensitive p53 Mutant. The Pathological Society of the republic of China, May 1995.Taipei, Taiwan, R.O.C.
  • Y.S.Lin and J.Y. Chuang.(1995)  A Movable and Regulable Inactivation Function within the Central Region of A Temperature-Sensitive p53 Mutant, Fifth Inernational Congress on Hormones and Cancer.  Sep 1995, Quebec, Canada.
  • Jing-Yuan Chuang, Chin-Tarng Lin, and Young-Sun Lin.(1995)  A Movable and Regulable Inactivation Function within the Core Domain of Tumor Supressor p53 Temperature-Sensitive Mutants. The tenth Joint Annual Conference of Biomedical Sciences, Mar1995.Taipei, Taiwan, R.O.C.
  • Jing-Yuan Chuang, Chin-Tarng Lin, and Young-Sun Lin.(1995)  A Movable and Regulable Inactivation Function within the Core Domain of Tumor Supressor p53 temperature-Sensitive Mutants. Third Symposium on Recent Advances in Cellular and Molecular Biology.  Feb 1995. Taiwan, R.O.C.

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