Chih-Rong Shyr, PhD (石志榮 博士)

Chih-Rong Shyr, PhD (石志榮 博士)

Associate Professor Department of Medical Laboratory Science and Biotechnology, China Medical University
Email: chshyr@mail.cmu.edu.tw
Phone: 886-4-22053366 ext. 7822
Fax: 886-4-22057414
Office: Rm 505, 5F, Cancer Center Building
Mailing Address: No. 6 Hsiuh-Shih Rd, Taichung, 40454, Taiwan, R.O.C.
40402 台中市學士路六號



Institution Nation Department/Program Degree Dates
University of Rochester   USA Pathology PhD From 1997 / 9 to 2002 / 6
National Yang-Ming Medical College Taiwan, ROC Biochemistry Master From 1991 / 9 to 1993 / 6
National Yang-Ming Medical College Taiwan, ROC Medical Technology Bachelor From 1987 / 9 to 1991 / 6


Current Position

Institution Department/Program Position Duration
China Medical University Department of Medical Laboratory Science and Biotechnology Associate Professor From 2011 / 2 to Now
China Medical University Hospital Sex Hormone Research Center Associate Research Fellow From 2010 / 8 to Now


Professional Experience

Institution Department/Program Position Duration
Chang Gung University Department of Chinese Medicine Assistant Professor From 2003 / 8 to 2007 / 7
Tzu Chi University Department of Medical Laboratory Science and Biotechnology Associate Professor From 2007 / 8 to 2010 / 7




Current Research of Chih-Rong Shyr's Lab

Sex Hormones and Sex Hormone Receptors

Research Goals

  1. Androgen-Androgen Receptor (A-AR) signaling on cell differentiation
    To determine the functions of d A-AR signaling on cell commitment and differentiation process and dissect the molecular mechanisms
  2. A-AR signaling involved in heart disease  
    To study the in vivo roles of AR in cardiovascular and cerebrovascular systems as well as its involvement in heart disease and stroke by using ARKO mice
  3. Estrogen-Estrogen Receptors (E-ERs) signaling involved in heart disease
    To study the in vivo roles of ERs in cardiovascular systems as well as their involvement in heart disease by using ERKO mice
  4. A-AR signaling involved in urinary tract urothelial cancer 
    To study the in vivo roles of AR in the initiation, progression and metastasis of upper urinary tract urothelial cancer by using ARKO mice



  1. Shyr CR*, Chen CC, Hsieh TF, Chang CH, Ma WL, Yeh S, Messing E, Li TH, Li FY, Chang C 2013 The expression and actions of androgen receptor in upper urinary tract urothelial carcinoma (UUTUC) tissues and the primary cultured cells. Endocrine 43:191-199
  2. Lai KP, Lai JJ, Chang P, Altuwaijri S, Hsu JW, Chuang KH, Shyr CR, Yeh S, Chang C 2013 Targeting thymic epithelia AR enhances T-cell reconstitution and bone marrow transplant grafting efficacy. Mol Endocrinol 27:25-37
  3. Hsu JW, Hsu I, Xu D, Miyamoto H, Liang L, Wu XR, Shyr CR, Chang C 2013 Decreased tumorigenesis and mortality from bladder cancer in mice lacking urothelial androgen receptor. Am J Pathol 182:1811-1820
  4. Hsieh TF, Chen CC, Yu AL, Ma WL, Zhang C, Shyr CR*, Chang C 2013 Androgen receptor decreases the cytotoxic effects of chemotherapeutic drugs in upper urinary tract urothelial carcinoma cells. Oncol Lett 5:1325-1330
  5. Hsieh TF, Chen CC, Ma WL, Chuang WM, Hung XF, Tsai YR, Lin MH, Zhang Q, Zhang C, Chang C, Shyr CR* 2013 Epidermal growth factor enhances androgen receptormediated bladder cancer progression and invasion via potentiation of AR transactivation. Oncol Rep 30:2917-2922
  6. Hsieh TF, Chen CC, Chang CH, Yu AL, Ma WL, Shyr CR* 2013 The potential use of primary human upper urinary tract urothelial cell carcinoma (UUT-UCC) cultured cells for prognostic indicators and chemosensitivity test. Exp Toxicol Pathol 65:703-708
  7. Chung WM, Chang WC, Chen L, Chang YY, Shyr CR, Hung YC, Ma WL 2013 MicroRNA-21 promotes the ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. Stem Cell Res Ther 4:88
  8. Chen L, Chang WC, Hung YC, Chang YY, Bao BY, Huang HC, Chung WM, Shyr CR, Ma WL 2013 Androgen Receptor Increases CD133 Expression and Progenitor-Like Population That Associate With Cisplatin Resistance in Endometrial Cancer Cell Line. Reprod Sci
  9. Chen CC, Hsieh TF, Chang CH, Ma WL, Hung XF, Tsai YR, Lin MH, Zhang C, Chang C, Shyr CR* 2013 Androgen receptor promotes the migration and invasion of upper urinary tract urothelial carcinoma cells through the upregulation of MMP-9 and COX-2. Oncol Rep 30:979-985
  10. Yu S, Yeh CR, Niu Y, Chang HC, Tsai YC, Moses HL, Shyr CR, Chang C, Yeh S 2012 Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts. Prostate 72:437-449
  11. Lin SJ, Ho HC, Lee YF, Liu NC, Liu S, Li G, Shyr CR, Chang C 2012 Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis. Reprod Biol Endocrinol 10:43
  12. Lin A M, Shyr CR (co-first author), Lin J 2012 Bread containing type 3 resistant starch reduced glycemic index and glycemic response in healthy young adults. Curr Top Nutraceutical Res 10:143-150
  13. Lai KP, Yamashita S, Vitkus S, Shyr CR, Yeh S, Chang C 2012 Suppressed prostate epithelial development with impaired branching morphogenesis in mice lacking stromal fibromuscular androgen receptor. Mol Endocrinol 26:52-66
  14. Chen M, Yeh CR, Shyr CR, Lin HH, Da J, Yeh S 2012 Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor alpha knockout mice. Asian J Androl 14:546-555
  15. Xie S, Ni J, Lee YF, Liu S, Li G, Shyr CR, Chang C 2011 Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation. J Biol Chem 286:21129-21136
  16. Tsai MY, Shyr CR (co-first author), Kang HY, Chang YC, Weng PL, Wang SY, Huang KE, Chang C 2011 The reduced trabecular bone mass of adult ARKO male mice results from the decreased osteogenic differentiation of bone marrow stroma cells. Biochem Biophys Res Commun 411:477-482
  17. Niu Y, Wang J, Shang Z, Huang SP, Shyr CR, Yeh S, Chang C 2011 Increased CK5/CK8-positive intermediate cells with stromal smooth muscle cell atrophy in the mice lacking prostate epithelial androgen receptor. PLoS One 6:e20202
  18. Kang HY, Shyr CR 2011 Activins and cell migration. Vitam Horm 85:129-148
  19. Shyr CR, Tsai MY, Yeh S, Kang HY, Chang YC, Wong PL, Huang CC, Huang KE, Chang C 2010 Tumor suppressor PAX6 functions as androgen receptor co-repressor to inhibit prostate cancer growth. Prostate 70:190-199
  20. Shyr CR, Kang HY, Tsai MY, Liu NC, Ku PY, Huang KE, Chang C 2009 Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells. Endocrinology 150:2454-2462
  21. Kang HY, Huang HY, Hsieh CY, Li CF, Shyr CR, Tsai MY, Chang C, Chuang YC, Huang KE 2009 Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer. J Bone Miner Res 24:1180-1193
  22. Tsai CL, Lin JW, Kuo HK, Tai MH, Wu YC, Shyr CR, Wu PC 2008 Induction of apoptosis in rabbit oral mucosa by 1.23% acidulated phosphate fluoride gel. Arch Toxicol 82:81-87
  23. Lan KC, Hseh CY, Lu SY, Chang SY, Shyr CR, Chen YT, Kang HY, Huang KE 2008 Expression of androgen receptor co-regulators in the testes of men with azoospermia. Fertil Steril 89:1397-1405
  24. Kang HY, Shyr CR, Huang CK, Tsai MY, Orimo H, Lin PC, Chang C, Huang KE 2008 Altered TNSALP expression and phosphate regulation contribute to reduced mineralization in mice lacking androgen receptor. Mol Cell Biol 28:7354-7367



  1. Pathology
    Study the mechanisms and biochemistry of diseases in different systems and link them to anatomy, tissue and cell morphology changes to have the full understanding of diseases