Distinguishing features of Research
The past five years, we devote our efforts to combining innovative biotechnology to develop new biological diagnostic markers, linking with traditional medicine, protein engineering technologies and nanotechnology to develop new anti-cancer and anti-infectious medicine. We try to integrate with the experience in basic research and clinical practice, through cooperation with other institutions and international organization, and then to accomplish the translational medical research. These studies raise the energies of teachers 'and students’ mutual learning, also stimulate students ' learning motivation .
Development of biological diagnosis markers and molecular testing methods
Using Proteomics technology and the knowledge of the mechanisms of cytokines formation and metastasis in cancer, and collaboration with clinicians, we have developed a biomarker for diagnosis of oral cancer saliva and pathological specimens, which increase the convenience of early diagnosis of oral cancer or promote a postoperative prognosis of the patient specimen, and provides effective further tracking. In the feature , we will also actively develop associated biomarkers for heart related and vascular diseases . Combined with quantitative PCR and high-resolution melt curve (HRM) analysis , we open up new molecular testing techniques, not only applied in the diagnosis of oral cancer molecular markers but also utilized to the typing of the clinical bacteria and classification of the influenza virus. These related technologies were cited by many published paper, and have been used in clinical laboratories. Through the study of bacterial drug resistance mechanism, we will dedicate to create new tests or treatments.
Developing new strategies for treatment of cancer and infectious disease
Cooperation with clinical physician, we strive to explore the new treatment strategy for oral and prostate cancer. We except to validate anticancer Chinese herb prescription, identifing effective anticancer extracted compounds, and also try hard to understand the carcinogenic and transfer mechanisms, especially in hormones and it’s receptor’s interaction in oral and prostate cancer, which further support to more efficiently exploit their possibilities for cancer target therapy.
In infectious disease research, we are committed to investigate the interactions between the factors on the virus to the host cell. We found that the factors associated with hepatitis C Virus replication will be a treatment target. During severe acute respiratory syndrome virus (SARS) and Japanese encephalitis virus (JEV) infection, they evade innate immunity, which provide new thinking on treatment. Immunity regulation plays an important role in viral and bacterial infections, we establish an animal model in immunity study to further understand the immune pathogenesis in infections. In addition, we also analyze the plant extracts on the immune regulation function, which also provides a new standard to develop this type of health food product. For the growing problem of drug resistance of the bacteria, we conducted a series test from basic mechanism to epidemiological studies , hoping to find new strategies to solve the problem.
Combined with nanotechnology platform for the development of detection and treatment of cancer and infectious disease
We create an advanced biomedical nanotechnology, that is the interdisciplinary study of chemical / biology / medical / engineering materials, and incorporate with nanotechnology, molecular biotechnology, protein engineering, virology, cell-mediated immunity and cancer biology. Further originate a fat-soluble derivative of Chinese herbal medicine delivery system to against cancer that is well integrate with other faculty’s research. These results have been published in internationally renowned journals, and applied for patents in many countries. We will also be actively development of percutaneous absorption of pharmaceutical nanocarriers and inhaled of target nanodrug delivery systems.